MNK1 signalling play a key role in invasive breast cancer growth (48), MNK1 inhibitors have been shown to block breast cancer proliferation in multiple cell lines (49), and its downstream target EIF4E is overexpressed in tumor versus normal samples from breast cancer patients (Figure 1G) and associated with a poor overall survival (Figure 1H). The gene discussed is MKNK1; the disease is breast carcinoma.