Given the similarity of the phosphorylation dynamics, peaking early at 5 and 15 minutes across Src, PIK3 and ESR1 within the complex induced by progestin (Figure 4C right panel) this may (similarly to the induction by oestrogen shown by others) present a novel ERa-ERK-cSrc activation mechanism in response to progestin in breast cancer cells. The gene discussed is ESR1; the disease is breast cancer.