More importantly, almost all tumorigenic-related pathways enriched in the high-TIM subgroup, including TP53, FOXM1, MYC, PLK1, and ATM signaling pathways, were related to regulating cell cycle, strongly suggesting the role of TIM to accelerate DNA replication and promote tumor cell proliferation, thereby worsening the prognosis of SKCM (30–33). This evidence concerns the gene PLK1 and neoplasm.