The possible explanations are listed: First, lnc-MAFG-AS1 promotes HCC migration and invasion in multiple ways, such as miR-6852, miR-3196-mediated OTX1, MYH9, MYL12B, and MYL6, to facilitate the development of multifocal nodules (13, 14). Here, OTX1 is linked to hepatocellular carcinoma.