STING1 and neoplasm: The resultant SN38 monomer construct was incorporated withina cationic triblock copolymer scaffold (poly(ethylene glycol-b-SN38 methacrylate-b-diethylaminoethylmethacrylate)) and subsequently self-assembled with DMXAA, a smallmolecule STING agonist specific to mice, to form 30 nm particles (pSN38-STING).In the reductive tumor microenvironment, the disulfide bonds are cleaved,and the pSN38-STING scaffold disassembles to trigger release of bothDMXAA and SN38.