INS and diabetes mellitus: An example of the promise of high-throughput polymersynthesis in drug candidate screening was recently reported by theAppel lab, where a screen of 90 polymer-functionalized insulins wasused to develop an ultrafast-acting insulin formulation with greaterstability and efficacy in a porcine model of diabetes.228 Here, polymer composition was shown to alterthe biodistribution, pharmacokinetics, and activity, highlightingthe impact that polymer design can have on downstream applications.