The underlying channelopathy pathway accounted for 46.7% (7/15) of the monogenic variants, including ion channel genes (SCN1A, KCTD7, KCNC1, CACNA1A, KCNMA1) and ligand-gated ion channel genes (GABRA1, GABRG2). This evidence concerns the gene CACNA1A and channelopathy.