MEG3 and Alzheimer disease: In AD, miR-155 (119), miR-128 (120), miR-129-5p (121), and miR-485-3p (122) were reported to up-regulate the expression of inflammatory mediators such as IL-6, and TNF-α, to aggravate neuroinflammatory injury in AD, while lncRNA-MEG3 (43) down-regulated the corresponding inflammatory mediators in the hippocampus thereby reducing neuroinflammation.