In the study of the AD mouse model, Zhang L. et al. found that MDA, OH, and lncRNA-SOX21-AS1 expression was significantly up-regulated in AD mice, accompanied by decreased levels of SOD, CAT, GSH-Px, FZD3 / 5, β-linked protein, etc. In contrast, silencing of SOX21-AS1 resulted in the opposite outcome and significantly reduced neuronal apoptosis in mice. This evidence concerns the gene FZD3 and Alzheimer disease.