IL1B and nervous system disorder: In their study, Iyer et al. found that the expression of miR-146a was induced by IL-1β, while the miR-146a mimic could reduce the mRNA level of IL-6 and COX-2 (the two main inflammatory molecules induced by IL-1β) in cultured human glial cells, indicating that it plays an important role in human chronic inflammation-related nervous system diseases (21).