The result indicated that overexpressed CBX7 and downregulated CBX8 in glioma cells showed a decreased expression of MMP2 and MMP9 (Figures 6J,K;, Supplementary Figures S2B,C) and displayed significantly lower invasion abilities in scratch wound-healing assay when compared to the control (Figure 6L;, Supplementary Figure S2D). Here, CBX8 is linked to central nervous system cancer.