CD4 and graft versus host disease: Corroborating the clinical findings, a preclinical study from the same research team confirmed CD4− iNKT cells, but not CD4+ iNKT cells, prevented GvHD using a xenograft NSG mouse model (Coman et al., 2018), and in vitro assays revealed that CD4− iNKT cells reduced the maturation and induced the apoptosis of human DCs (Coman et al., 2018).