The expression of lncRNA pacer in alveolar macrophages of ALI patients and lung tissues of ALI mice was significantly increased; after overexpression of pacer, tumor necrosis factor-α (TNF-α) the expression of TNF was increased, while after knockdown of pacer, the inflammatory factor TNF-α,the expression of IL-6 decreased; TNF in lung tissue and serum of ALI mice after pacer knockdown-α, the expression of IL-6 decreased significantly, and the degree of lung injury decreased significantly. This evidence concerns the gene TNF and acute respiratory distress syndrome.