NLRP3 and Parkinson disease: Quercetin (Qu), a health supplement exerting anti-inflammatory and antioxidant effects, was shown to prevent mtROS accumulation and attenuate NLRP3 inflammasome activation and IL-1β release by promoting mitophagy in microglia, which ultimately alleviated the loss of DA neurons in PD mice (Han et al., 2021b).