PINK1 and Parkinson disease: Using mito-QC as an in vivo mitophagy reporter, a recent study demonstrated that basal mitophagy in mouse tissues with high metabolic demand such as microglia and PD-relevant mesencephalic DA neurons, occurred independently of PINK1, as loss of Pink1 did not have any obvious effect on basal mitophagy in these cells/tissues (McWilliams et al., 2018).