Dong et al. (2021) demonstrated the pivotal role of IGF2BP1 in promoting angiogenesis and atherosclerosis. Given the crucial roles of atherosclerosis and macrophages in the pathogenesis of IAs, we speculated that IGF2BP1 could also be involved in the formation and development of IAs combined with inflammation. Although the roles of LRPPRC, YTHDF3, and ZNF217 in cardiovascular diseases have rarely been investigated, the potential interplay between them with immune activity has been identified (Refolo et al., 2019; Zhang et al., 2019). The gene discussed is ZNF217; the disease is cardiovascular disorder.