APOE and cerebrovascular disorder: The other potential factors such as sleeping disturbance (Cordone et al., 2019), ApoE type (Vemuri et al., 2017), physical activity (Pedrero-Chamizo et al., 2021), and cerebrovascular disease (Saito and Ihara, 2016) are ideally also to be analyzed, because they may be linked to disease progression through amyloid and tau deposition or other pathways.