LEP and obesity due to melanocortin 4 receptor deficiency: During obesity-induced stress, white and brown adipocytes secrete unbalanced levels of adipokines (augmented proinflammatory and diminished anti-inflammatory mediators), including low levels of adiponectin and of BAT’s adipokines as Fibroblast growth factor 21 (FGF21) and C-terminal fragment of SLIT2 protein (SLIT2-C), also increased amounts of BAT mediators such as Chemerin and Endothelin-1 (ET-1), and WAT secreted leptin [55].