An enhanced inflammatory profile is one of the main features of cachexia and it is well established that increased circulating levels of cytokines, such as TNF-α, IL-1β, IL-6, and IFNγ, secreted by both immune and non-immune cells, including tumor cells, modulate pathways related with several catabolic processes in skeletal muscle and adipose tissue [96]. This evidence concerns the gene IFNG and neoplasm.