PLOD1 and polycystic ovary syndrome: Furthermore, compared with the control group, the rats with PCOS exhibited an increased level of LH, FSH, and testosterone, as well as an increased LH/FSH value (compared with the Control group, P<0.001), which was reduced by AS-IV treatment in a dose-dependent manner (compared with PCOS group, P<0.01 and P<0.001; compared with +AS-IV 20 mg/kg group, P<0.01 and P<0.001; compared with +AS-IV 40 mg/kg group, P<0.01 and P<0.001) (Figures 1D-G).