STAT3 and chronic myelogenous leukemia, BCR-ABL1 positive: Since apoptotic, STAT3 protein expressional and metabolic regulations seemed to be dependent on their interactions within each other, and CML cells relied on glycolytic and mitochondrial functions to provide high energy and metabolic needs for escaping apoptosis, we initially analyzed whether both nilotinib sensitive and resistant leukemic cells showed resistance to apoptotic cell death and then, we checked the correlation between low apoptosis rates and high phosphorylated forms of STAT3 protein expression levels (33–35).