INS and metabolic dysfunction-associated steatotic liver disease: In line with our results, previous reports found that high-fat emulsion (HFE) and small doses of lipopolysaccharides (LPS) for 5 weeks in Wistar rats caused adipocyte dysfunction associated with increased blood glucose levels, insulin levels, and insulin resistance in NAFLD which were decreased by saroglitazar (4 mg/kg/day, PO) treatment given from the 3rd week to the 5th week (53).