Xia et al. (2020) also reported that ganoderic acid DM (which belongs to triterpenoid) proves to induce autophagy apoptosis in non-small cell lung carcinoma via inhibition of PI3K/Akt/mTOR pathway. Aside from that, Tyler et al. (2015) discovered that dl-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (dl-PPMP) potentiates cisplatin cytotoxicity in acquired cisplatin-resistance of lung carcinoma and malignant pleural mesothelioma. The gene discussed is AKT1; the disease is malignant pleural mesothelioma.