Cheng et al. (2020) observed a superantigenic insert, which is a unique S-glycoprotein, in SARS-CoV-2, and concluded that the insert might be responsible for causing hyper inflammation in patients with severe COVID-19 (Cheng et al., 2020). SAgs can excessively activate the immune system. Previous studies have identified SAgs from viruses (Lafon, 2000). A SAg-like region (PRRA) was recently detected in this virus S-glycoprotein of the Wuhan strain (Cheng et al., 2020). Here, ART4 is linked to COVID-19.