Our results suggest that overexpressing miR-657 was sufficient to upregulate Slug, Vimentin, and N-cadherin while promoting the downregulation of E-cadherin in both NCI-H1650 and A549 cells, suggesting that this miRNA can function as an oncogene to promote EMT induction in NSCLC cells. Here, CDH2 is linked to non-small cell lung carcinoma.