Immunohistochemical results showed that the expression of TrkB and its ligand brain-derived neurotrophic factor (BDNF) in endometrial cancer was significantly increased (P < 0.05), and its high level of TrkB was associated with lymph node metastasis and lymphatic vessels Interstitial involvement is closely related (P < 0.05). Here, BDNF is linked to endometrial cancer.