CNR2 and schizophrenia: This hypothesis that CB2 receptors may play a role in schizophrenia-related behaviors is further supported by rodent studies in which deficits in sensorimotor gating as assessed with prepulse inhibition (PPI) induced by the NMDA receptor antagonist MK-801 can be exacerbated by a CB2-selective antagonist (Ishiguro et al., 2010), and reversed by a CB2 agonist (Khella et al., 2014).