As reviewed below, not only is CB2 expressed in these schizophrenia-relevant brain regions, but activation of CB2 has circuit-level effects that would be expected to normalize hyperactive dopaminergic as well as hippocampal and cortical signaling which would further support the potential of CB2-selective compounds as a novel therapeutic strategy for treating schizophrenia. The gene discussed is CNR2; the disease is schizophrenia.