According to the above description, combined with a study that found that CA 125 level is related to anxiety and depression (De Moor et al., 2006), we speculate that it may be due to factors such as sleep rhythm disorder mediated by clock genes and anxiety and depression in NSSI group, resulting in the increase of tumor marker level in NSSI (Koritala et al., 2021). This evidence concerns the gene CLOCK and depressive disorder.