In the pathological progression of AD, different species of Aβ aggregates, tau oligomers and fibrils, and damaged neurons could induce microglia activation and the production of pro-inflammatory cytokines and chemokines, all of which could lead to neuronal dysfunction and death (Sondag et al., 2009; Heppner et al., 2015; Hansen et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.