Furthermore, recently, a GGC-repeat expansion in the Notch 2 N-terminal like C (<i>NOTCH2NLC</i>) gene, which produces a toxic polyglycine-containing protein (uN2CpolyG) in patients with NIID, has been associated with the pathogenesis of ALS. The gene discussed is NOTCH2; the disease is amyotrophic lateral sclerosis.