Men with DS (age > 35) had 34% higher exosomal P-T181-Tau compared to age-matched women with DS; opposite effect seen in non-trisomic group. No sex differences observed in exosomal Aβ1-42 and P-S396-Tau in both trisomic and non-trisomic groups. The gene discussed is MAPT; the disease is Dravet syndrome.