PLOD1 and Hypoglycemia: Furthermore, IV administration of naloxone restored LH pulses that were suppressed by insulin-induced hypoglycemia in OVX ewes (Clarke et al., 1990), and IV injections of naloxone restored LH pulses that were suppressed by the administration of an endotoxin lipopolysaccharide in OVX heifers (Kujjo et al., 1995) and OVX rhesus monkeys (Xiao et al., 2000).