Combined with previous findingss, our resultsindicated that, stroke model group compared with sham group, the contents of IL-6, TNF-α, and IL-17 in cerebral cortex, serum, and colonic tissues were significantly increased (P < 0.05), and contents of TGF-β and IL-10 obviously were decreased (P < 0.05), demonstrating severe inflammatory reaction occurred in rats. Here, IL6 is linked to Stroke.