A study by Lee et al. on the association between BIRC6 expression rate and clinical symptoms of esophageal squamous cell carcinoma in 80 patients did not show any significant association between BIRC6 expression rate and variables such as age, sex, size, and differentiation of the cancer cells, while the relationships with lymph node involvement, stage, and metastasis were significant [21]. This evidence concerns the gene BIRC6 and cancer.