The core proteins determined by PPI were TP53, AKT1, Myc, EGFR, CCND1, JUN, CASP3, STAT3, etc. Among these, AKT1 and AKT2 gene knockout have been shown to reduce metastasis and growth of colon cancer [17]. The gene discussed is AKT1; the disease is malignant colon neoplasm.