PPARG and neoplasm: Since PPARG was not in our targeted panel, we performed a Sanger sequencing of the hotspot region within the ligand-binding domain of PPARG (26) and identified one patient tumor/PDX pair (B521) harboring the T475M-activating mutation (n=1/23 tested PDX) and one patient tumor/PDX pair (M559) harboring the non-characterized and non-recurrent L339F mutation (26).