Functionally, the overexpression of LINC00152 promotes the proliferation, invasion, and migration of ESCC cells in vitro and also regulates the interaction between mitotic arrest-deficient 2-like 1 (MAD2L1) and cyclin-dependent kinase 6 (CDK6) in vesicle transport pathway proteins, and syntaxin 3 (STX3) and STX12 soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor (SNARE) family members (64). The gene discussed is CDK6; the disease is esophageal squamous cell carcinoma.