DHODH and hepatocellular carcinoma: By performing univariate and multivariate logistic regression analysis on three coexisting genes (ABCC5, DHODH, and TUBG1) in TCGA HCC dataset, it was found that ABCC5 and TUBG1 were independent risk factors for HCC (OR>1; P <0.05), whereas DHODH was an independent protective factor in HCC (OR<1; < 0, 05) (Table 2).