Based on bioinformatics analysis, earlier studies have established that telomerase reverse transcriptase (hTERT) (9), hypoxia-inducible transcription factor-2a (HIF-2α) (10), S100 calcium-binding protein A11(S100A11) (11), squalene epoxidase (SQLE) (12), and deoxycytidine kinase (DCK) (13) were associated with NAFLD to HCC progression and prognosis and could act as a related marker. Here, S100A11 is linked to metabolic dysfunction-associated steatotic liver disease.