Notably, a prognostic nomogram based on five Hippo-related genes (i.e., the master regulator of cell cycle and proliferative metabolism (MYC), neurofibromatosis 2 (NF2), misshapen-like kinase 1 (MINK1), baculoviral IAP repeat-containing 3 (BIRC3), and casein kinase 1 epsilon (CSNK1E)) has been proposed, outperforming available clinical parameters in the prognostication of HCC (99). The gene discussed is CSNK1E; the disease is hepatocellular carcinoma.