SPON2 and hepatocellular carcinoma: PDZ and LIM domain 1 (PDLIM1), ACTN1, mitochondrial ACADL, and matricellular spondin-2 (SPON2) expressions involved in mechanisms such as enhancing the Hippo pathway activity, reducing RhoA GTPases activity, repressing cell proliferation, repressing tumor growth, facilitating interaction with MOB1, decreasing phosphorylation of LATS1 and YAP, M1-macrophage recruitment facilitation, and suppression hepatocellular carcinoma metastases have been implicated in prognosticating HCC (75, 100–102) (Table 1).