Accordingly, several investigators have revealed that targeting NatB-mediated protein N-α-terminal acetylation (NATB) expression, Neuronally Expressed Developmentally Downregulated 4 (NEDD4)/LATS1 pathway, Herpesvirus-associated ubiquitin-specific protease (HAUSP) expression, Cip1-interacting zinc finger protein 1 (CIZ1) expression, and phosphorylated-ezrin (p-Ezrin) effectively arrested carcinogenesis in HCC (77–81). This evidence concerns the gene EZR and hepatocellular carcinoma.