Several other targets inhibit HCC cells proliferation, growth, and migration and induce apoptosis through different mechanisms such as RSPO2/Hippo/Yap and S1P2-induced Yap activation, EGF-induced Erb-B2 receptor Tyrosine Kinase 2 (ErBB2) and PI3K/AKT activation, and Junctional Cadherin 5 Associated with coronary artery disease (JCAD)/LATS1 interaction (86–89). The gene discussed is YAP1; the disease is hepatocellular carcinoma.