Seemingly, Septin 6 (SEPT6), Frizzled-2, MORC Family cw-Type Zinc Finger 2 (MORC2), Ubiquitin-specific protease 11 (USP11), Yki/Yap-Src42A/SRC positive feedback loop, m6A methyltransferase 3 (METTL3), and family with sequence similarity 83 member D (FAM83D) play crucial roles in HCC tumorigenesis by promoting vascular mimicry, cell stemness, migration, invasion, and silencing of the Hippo pathway by DNA methylation-dependent mechanism. This evidence concerns the gene YAP1 and hepatocellular carcinoma.