Thus, novel lncRNAs mediating their effects by CUL4A-mediated ubiquitination of large tumor suppressor kinase 1 (LATS1), enhancing YAPS127 phosphorylation, and activating the tumor-suppressive Hippo pathway (miR-106b-5p/LATS1) have been deemed potential HCC treatment options leading to tumor growth inhibition (27, 28) (Table 1). This evidence concerns the gene CUL4A and neoplasm.