H19 and neoplasm: While FP-RMS is associated with chromosomal translocations that encode altered transcription factors, FN-RMS is notably associated with loss-of-heterozygosity (LOH) in the chromosomal region 11p15.5 which harbors tumor suppressive IGF2, H19, and CDKN1C genes, chromosomal gains and losses, TP53 mutations, and increased expression of the HRAS oncogene (10, 11).