However, nine (9/35, 25.71%) PJS unrelated families with point variants (n = 5) or large deletions (n = 4) in the STK11 exon one developed cancers in probands and/or the affected relatives were associated with the digestive system, as well as with lung, breast, and gynecological cancers. The gene discussed is STK11; the disease is Peutz-Jeghers syndrome.