Only little information is available regarding the role of p19INK4d in human malignancies; frame shift mutations and rearrangements in the p19INK4d gene have been documented in osteosarcoma (76), while its loss or downregulation have been detected in hepatocellular carcinoma (77) and testicular germ cell tumors (78). Here, CDKN2D is linked to osteosarcoma.