Selective p15INK4b promoter hypermethylation, without p16INK4a alterations, is observed in acute myeloid leukemia (AML), myelodysplastic syndrome and ALL (140, 142–146), whereas Burkitt’s lymphoma and Hodgkin’s lymphoma present p16INK4a hypermethylation (140, 141, 147–150). This evidence concerns the gene CDKN2B and acute myeloid leukemia.