In TCGA datasets, among WHO grade 3 glioma,MLLT11 showed a highly negative correlation with PD-1 (r = -0.34, p = 8.3 × 10-28), PD-L1 (r = -0.41, p = 3.5 × 10-11), TIM3(HAVCR2) (r = -0.4, p = 1.2 × 10-11), and PD‐L2 (PDCD1LG2) (r = -0.58, p < 2.2 × 10-16) (Figure 6). Here, CD274 is linked to central nervous system cancer.