For the high HMOX1 group, activities of the majority of the cancer-immune cycles were found to be up-regulated, including release of cancer antigens (step1), cancer antigen presentation (step 2), priming and activation (step 3), trafficking of immune cells to tumors (step 4, like CD4 T cell, CD8 T cell, macrophage, monocyte, Treg cell), and infiltration of immune cells into tumors (step 5). This evidence concerns the gene CD4 and cancer.