Notably, though ARHIGH/NEHIGH cells present a higher level of metabolism activity (Figure 4F), ARLOW/NEHIGH cells still have a higher proliferation potential as determined by enriched pathways associated with cell cycle and cell proliferation (Figure 4G), corresponding to the higher malignancy of AR- prostate cancer with neuroendocrine differentiation compared with AR+. This evidence concerns the gene AR and Familial prostate cancer.