AR and Familial prostate cancer: To investigate the AR status in prostate cancer with neuroendocrine differentiation, we first analyzed the bulk RNA sequencing datasets consisting of hormone-naïve prostate cancer cohorts (TCGA (19), SMMU (20), and DKFZ (21)) and castration-resistant prostate cancer cohorts (GSE77930 (22), GSE147250 (23), SU2C/PCF (24), and Beltran 2016 (14)).