EIF2AK4 and acute myeloid leukemia: After treatment with erastin or sulfasalazine, the mRNA expression levels of the remaining six prognostic ferroptosis-related genes were changed, except for the mRNA expression levels of EIF2AK4. SOCS1, a suppressor of cytokine signaling 1, has been shown to interact with P53 to regulate ferroptosis (27), and its high expression has been associated with poor prognosis in patients with AML (28).