As shown in the baseline patient characteristics (Table 1), PCa-associated risk factors, including age, PSA, prostate volume, %fPSA, DRE, PSAD, PCA3 score and lncRNA546 score, were all statistically significant in their ability to differentiate prostate cancer from negative biopsies in the overall cohort. The gene discussed is KLK3; the disease is Familial prostate cancer.