To explore the mechanism by which CCL5/CCR5 promotes tumor metastasis, we conducted GO and KEGG enrichment analyses on CCL5- and CCR5-related genes, which showed that the genes enriched by CCL5/CCR5 were mainly enriched in immune-related signaling pathways, such as the T-cell receptor signaling pathway, immune response, T-cell costimulation, and T-cell activation. The gene discussed is CCL5; the disease is neoplasm.