Recently, several large-scale sequencing and multiplatform studies have demonstrated some genes closely related to the occurrence and development of ESCC, such as TNFAIP3 (encodes tumor necrosis factor-induced protein 3), CHN1 (encodes chimerin 1), KMT2D (encodes lysine methyltransferase 2D) and NFE2L2 (encodes nuclear factor erythroid 2-like 2), EGFR (encodes epidermal growth factor receptor), etc. (8–10). This evidence concerns the gene CHN1 and esophageal squamous cell carcinoma.