To quantify CD4+ T-cell response, we measured CD4+ T-cell response by CD4+ T-cell markers (CD3D, CD3E, CD4, and CD40LG), which was also highly expressed in immune-high ND MM samples (Figure 3F) and significantly associated with MHC-II expression (Figure 3G). The gene discussed is CD3D; the disease is Miyoshi myopathy.