One such study evaluated the relationship between cognitive performance (executive function, memory, and psychomotor speed) and the intratumoral expression levels of molecular markers in patients with diffuse glioma prior to treatment; after correction of tumor volume and location, significant associations were identified between expression levels of CD3 and IDH-1 and psychomotor speed, as well as between IDH-1, ATRX, NLGN3, BDNF, CK2Beta, EAAT1, GAT-3, SRF, and memory performance, and between IDH-1, P-STAT5b, NLGN3, CK2Beta, and executive functioning (70). This evidence concerns the gene IDH1 and neoplasm.