TNFRSF1A encodes the TNFα receptor. TNFα and IL6 induce sustained NF-κB activity, aberrant activation of STAT3, and increased expression of pro-oncogenic proteins. The cross-talk between NF-κB and STAT3 induces tumor progression and facilitates cancer stemness in gliomas. This evidence concerns the gene TNFRSF1A and central nervous system cancer.