The inoculation of KP-HELLO cells in B cell knockout or TFH knockout mice showed much faster tumor growth and weaker CD8+ T cell function compared to tumor growth inoculated in WT mice, suggesting that the GC B cells that recognize the neoantigen and further interact with activated CD4+ T cells are able to support CD8+ T cells function in TME. The gene discussed is CD4; the disease is neoplasm.