Except for the in-depth insight into the biological functions of the above-mentioned four CRGs, 19 other identified CRGs involved in the signature, namely, ANAPC4, MMAB, B9D2, NDEL1, SLC25A15, PSMA7, PSMB10, PSMB5, PSMB8, RAD9A, REXO2, ARID3A, CHMP4C, DDX39B, FBXO31, FBXO6, PRPF19, RGCC, and TIPIN, were first identified to play a potential role in BC progression, and their detailed functions remained enigmatic, which merited further experimental verification. The gene discussed is RAD9A; the disease is breast cancer.