HMMR and glioblastoma: Upregulated in Glioblastoma stem cells GSC relative neural stem cells.Associated with poorer overall survival in mesenchymal glioblastoma patients.Knockdown of HMMR repressed proliferation of GSC and reduced their ability to form neurospheres.Downregulation of HMMR reduced the expression of stem cell markers and transcription factors.HMMR knockdown in GSC cells had reduced ability to form tumors compared to HMMR competent cells in vivo.