HMMR and Familial prostate cancer: Overexpression is associated with biochemical recurrence, increased Gleason score and poorer prognosis.RHAMM expression is increased in metastatic tumors and mediates cell migration in prostate cancer cells.Androgen and Retinoblastoma regulated gene.RHAMM activates ROCK pathway to promote the development of castration resistance.RHAMM expression increases with the duration of ADT therapy.Potential biomarker for disease progression.HMMR is a hypoxia induced gene.