Among all the significant findings of the correlation between variants of ERCC4 and ERCC5 and cancer risk, little heterogeneity (I2 ≤ 25%) was discovered in 29 (53.7%) relationships; moderate (25% < I2 < 50%) and large (I2 ≥ 50%) heterogeneity were figured out in 6 (11.1%) and 19 (35.2%) associations.(Table 1) The results of sensitivity analysis are shown in Table 1. Here, ERCC5 is linked to cancer.