In current study, 55,446 cases of 19 types of cancer and 61,855 controls were enrolled in these 192 datasets for the investigation of the implication of 40 ERCC4 variants on cancer susceptibility, and as for ERCC5, we collected 38 SNPs distributed in 55,393 cases of 22 types of cancer and 66,872 controls. This evidence concerns the gene ERCC4 and cancer.